Reverse fountain flow of phosphatidylinositol‐3,4‐bisphosphate polarizes migrating cells
نویسندگان
چکیده
منابع مشابه
Stem cells: the chameleon fountain of youth.
Senescence requires rejuvenation of organs critical to survival. To date, efforts at “rejuvenation” of the heart have largely used replacement (orthotopic transplantation) and, more recently, mechanical biventricular assist devices. These strategies have been hampered by the limited availability of donor organs and the high levels of immunosuppression required to prevent transplanted organ reje...
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A major neurotransmitter dopamine transmits signals via five different seven transmembrane G protein-coupled receptors termed D1-D5. It is now evident that dopamine is released from leukocytes and acts as autocrine or paracrine immune modulator. However, the role of dopamine for dendritic cells (DCs) and T(h) differentiation remains unclear. We herein demonstrate that human monocyte-derived den...
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Cell migration is crucial for processes such as immune defense, wound healing, or the formation of tumor metastases. Typically, migrating cells are polarized within the plane of movement with lamellipodium and cell body representing the front and rear of the cell, respectively. Here, we address the question of whether this polarization also extends to the distribution of ion transporters such a...
متن کاملGalactic dynamo and helicity losses through fountain flow
Aims. Nonlinear behaviour of galactic dynamos is studied, allowing for magnetic helicity removal by the galactic fountain flow. Methods. A suitable advection speed is estimated, and a one-dimensional mean-field dynamo model with dynamic α-effect is explored. Results. It is shown that the galactic fountain flow is efficient in removing magnetic helicity from galactic discs. This alleviates the c...
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Slime molds provide a textbook example of self-organization. They live as single cells until food becomes scarce. Then, they broadcast chemical signals that trigger their mass assembly into a fruiting body, with some cells forming a stalk and others turning into spores that cast about in the winds to spread far and wide. Neurons in the developing brain complete their own self-organized waltz, c...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2021
ISSN: 0261-4189,1460-2075
DOI: 10.15252/embj.2020105094